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In the mid 1940s Procter and Bet started an examination program to track down fixings that, when added to a toothpaste, would diminish tooth rot. Around then, Americans fostered an expected 700 million cavities per year, making dental illness one of the most predominant U.S. medical conditions. In 1950, Procter and Bet shaped a joint exploration project group headed by Dr. Joseph Muhler at Indiana College to create and test another toothpaste with fluoride. Possible energizing outcomes from a clinical investigation of this toothpaste demonstrated that kids ages six to 16 showed a typical 49% decrease in holes, and grown ups showed tooth rot decrease to practically a similar degree. Following the progress of this review, Peak with Fluoristan toothpaste sent off into various test markets in 1955, trailed by public development in January, 1956.